evaluation of serum interleukin-18 levels in helicobacter pylori-infected peptic ulcer patients and its association with bacterial caga virulence factor
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abstract
background: helicobacter pylori infection is one of the most common gastrointestinal infections worldwide. predominant t-helper 1 (th1) responses with increased gamma interferon (ifn- γ) levels have been proposed to play an important role in h. pylori-induced peptic ulcer. however, bacterial factors contributing to the initiation of th1 polarization of h. pylori-specific immune responses have not been characterized. objective: comparing serum concentrations of il-18 in h. pylori-infected peptic ulcer (pu) patients, h. pylori-infected asymptomatic (as) carriers and healthy control group and its association with bacterial virulence factor caga. methods: thirty h. pylori-infected pu patients (20 patients were positive for anti-caga antibody and 10 patients were negative for anti-caga antibody), 30 h. pylori-infected (as) carriers (15 subjects with positive test for anti-caga antibody and 15 subjects with negative test for anti-caga antibody) and 20 healthy uninfected subjects were included in this study. serum concentration of il-18 was measured by elisa method. results: the mean serum levels of il-18 in pu patients (333.2 pg/ml ± 158), was significantly higher than those found in as (146.5 pg/ml ± 90.1; p
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Journal title:
iranian journal of immunologyجلد ۳، شماره ۱، صفحات ۱۵-۲۲
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